Pharmacy Times – July 2017

 

Drug Interactions: Insights and Observations

 

Piperine Drug Interactions

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References.

1. Bedada SK, Appani R, Boga PK. Effect of piperine on the metabolism and pharmacokinetics of carbamazepine in healthy volunteers. Drug Res. 2017;67:46-51.

2. Pattanaik S, Hota D, Prabhakar S, Kharbanda P, Pandhi P. Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res. 2009;23:1281-1286.

3. Rezaee MM, Kazemi S, Kazemi MT, Gharooee S, Yazdani E, Gharoee H, Shiran MR, Moghadamnia AA. The effect of piperine on midazolam plasma concentration in healthy volunteers, a research on the CYP3A-involving metabolism. DARU Journal of Pharm Sci. 2014;22:8.

4. Bedada SK, Boga PK, Kotakonda HK. Study on influence of piperine on the pharmacokinetics of diclofenac in healthy volunteers. Xenobiotica 2017;47:127-132.

5. Bano G, Amla V, Raina RK, Jutshi U, Chopra CL. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med. 1987;53:568-569.

6. Pattanaik S, Hota D, Prabhakar S, Kharbanda P, Pandhi P. Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. Phytother Res. 2006;20:683-686.

7. Bedada SK, Boga PK. The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers. Eur J Clin Pharmacol. 2017; 73:343-349.

8. Bedada SK, Boga PK. Effect of piperine on CYP2E1 enzyme activity of chlorzoxazone in healthy volunteers. Xenobiotica. 2016. DOI:10.1080/00498254.2016.1241450.

9. Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991;41:615-617.