Avoiding Lapatinib Interactions

 

November 2012

 

John R. Horn, PharmD, FCCP, and Philip D.  Hansten, PharmD

 

References:

 

1. Teo YL et al. Efffect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Res Treat. 2012;133:703-711.

2. Smith DA et al. Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects. Br J Clin Pharmacol. 2009;67:421-426.