Pharmacy Times – October 2012

 

Drug Interactions: Insights and Observations

 

Enzyme Inducer Plus Enzyme Inhibitor: What Will Happen?

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

 

References

 

1. Hafner V et al Effect of simultaneous induction and inhibition of CYP3A4 by St John’s wort and ritonavir on CYP3A4 activity. Clin Pharmacol Ther. 2010;87:191-6.

2. Decloedt EH et al. Pharmacokinetics of lopinavir in HIV-infected adults receiving rifampin with adjusted doses of lopinavir-ritonavir tablets. Antimicrob Agents Chemother. 2011;55:3195-200.

3. Duval X et al. Efavirenz-induced decrease in plasma amprenavir levels in human immunodeficiency virus-infected patients and correction by ritonavir. Antimicrob Agents Chemother. 2000;44:2593.

4. Song I et al. Effects of Etravirine alone and with ritonavir-boosted protease inhibitors on the pharmacokinetics of dolutegravir. Antimicrob Agents Chemother. 2011;55:3517-21.