PHARMACY TIMES

 

Drug Interactions: Insights and Observations

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

Narcotic Analgesic Metabolized by CYP2D6

 

 

References:

1. Tirrkkonen T et al. Drug interactions with potential to prevent prodrug activation as a common source of irrational prescribing in hospital inpatients. Clin Pharmacol Ther.2004;76:639.
2. Shidrup SH et al. The effect of quinidine on the analgesic effect of codeine. Eur J Clin Pharmacol.1992;42:587.
3. Caraco Y et al. Impact of ethnic origin and quinidine coadministration on codeine’s disposition and pharmacodynamics effects. J Pharmacol Exp Ther.1999;290:413.
4. Gasche Y et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. NEJM.2004;351:2827.
5. Wilder-Smith CH et al. The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers. Br J Clin Pharmacol.1998;45:575.