Pharmacy Times – April 2010

 

Drug Interactions: Insights and Observations

 

Drug Interactions with Tyrosine Kinase Inhibitors

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References

 

 

1.     Labeling for Dasatinib (Sprycel), Erlotinib (Tarceva), Gefitinib (Iressa), Imatinib (Gleevec), Lapatinib (Tykerb), Nilotinib (Tasigna), Pazopanib (Votrient), Sorafenib (Nexavar), and Sunitinib (Sutent).

2.     Swaisland HC et al. Pharmacokinetic drug interactions of Gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet. 2005;44:1067.

3.     Frye RF et al. Effect of St John’s wort on Imatinib mesylate pharmacokinetics. Clin Pharmacol Ther. 2004;76:323.

4.     Hartman JT et al. Tyrosine kinase inhibitors – a review on pharmacology, metabolism and side effects. Curr Drug Metab. 2009;10:470.

5.     Hamilton M et al. Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006;12:2166.