Pharmacy Times October 2018

 

Drug Interactions: Insights and Observations

Valproic Acid / Carbapenem Antibiotics Interaction

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

References

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2. Ishikawa T, Otaki H, Mizuta S et al. Computational study of the competitive binding of valproic acid glucuronide and carbapenem antibiotics to acylpeptide hydrolase. Drug Metab Pharmacokinet. 2017;32:201-7.

3. Wu CC, Pai TT, Hsiao FY et al. The effect of different carbapenem antibiotics (ertapenem, imipenem/cilastatin, and meropenem) on serum valproic acid concentrations. Ther Drug Monit. 2016;38:587-92.

4. Wen Z-P, Fan S-S, Du C et al. Drug-drug interaction between valproic acid and meropenem: a retrospective analysis of electronic medical records from neurosurgery inpatients. J Clin Pharm Ther. 2017;42:221-7.

5. Velez-Diaz-Pallares M, Silveira ED, Diaz AM, et al. Analysis of the valproic acid-meropenem interaction in hospitalized patients. Neurologia. 2012;27:34-8.

6. Haroutiunian S, Ratz Y, Rabinovich B et al. Valproic acid plasma concentration decreases in a dose-independent manner following administration of meropenem: a retrospective study. J Clin Pharmacol. 2009;49:1363-9.

7. Huang CR, Lin CH, Hsiao SC et al. Drug interaction between valproic acid and carbapenems in patients with epileptic seizures. Kaohsiung J Med Sci. 2017;33:130-6.

8. Herrero MCM, Romero AJA, Vilaplana VE et al. Pharmacological interaction between valproic acid and carbapenem: what about levels in pediatrics? Eur J Paediat Neurol. 2015;19:155-61.

9. Doribax [package insert]. Osaka, Japan; Shinogi Inc., 2015.

10. Masuo Y, Ito K, Yamamoto T et al. Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide. Drug Metab Dispos. 2010;38:1828-35.