Drug Interactions Where Both Drugs are Affected

November 2017

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





1. Zhang C, Shen L, Cui M, Liu X, Gu Z. Ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction. A case report. Medicine. 2017;96:e8065. doi:10.1097/MD.0000000000008065


2. Horn JR, Hansten PD, Chan L-N. Proposal for a New Tool to Evaluate Drug Interaction Cases. Ann Pharmacotherapy. 2007;41:674-680.


3. van Sloten, de Klaver PAG, ven den Wall Bake AWL. Co-administration of cyclosporine and ticagrelor may lead to a higher exposure to cyclosporine: a case report of a 49-year-old man. Br J Clin Pharmacol. 2017;Sept 11: doi: 10.1111/bcp.13433