Pharmacy Times – June 2016

 

Drug Interactions: Insights and Observations

 

Drug Interaction Mechanisms: Inhibition of CYP450 Metabolism

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References

 

1. Zhou S, Chan S, Goh B et al. Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet. 2005;44:279-304.

2. Okudaira T, Kotegawa T, Imai H et al. Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans. J Clin Pharmacol. 2007;47:871-6.

3. Katzenmaier S, Markert C, Riedel K-D et al. Determining the time course of CYP3A4 inhibition by potent reversible and irreversible CYP3A4 inhibitors using a limited sampling strategy. Clin Pharmacol Ther. 2011;90:666-73.