Pharmacy Times – June 2014


Drug Interactions: Insights and Observations


Statins and OATP Interactions


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





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2. Niemi M et al. Organic anion transporting polypeptide 1b1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011;63:157-81.

3. Ichimaru N et al. Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus. Atherosclerosis. 2001;158:417-423.

4. Pasanen MK et al. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics. 2006;16:873-879.

5. Backman JT et al. Plasma concentrations of active simvastatin acid are increased by gemfibrozil. Clin Pharmacol Ther. 2000;68:122-129 ().

6. The SEARCH collaborative group. SLCO1B1 variants and statin-induced myopathy – a genome wide study. New Engl J Med.2008;359:789-99.

7. Whitfield LR et al. Effect of gemfibrozil and fenofibrate on the pharmacokinetics of atorvastatin. J Clin Pharmacol. 2011;51:378-388.