Pharmacy Times – June 2012


Drug Interactions: Insights and Observations


Genetics and Enzyme Inhibitor Interactions


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD






1. Mikus G et al. Potent cytochrome P45o 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir. Clin Pharmacol Ther. 2006;80:126-35.

2. Saito M et al. Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes. Br J Clin Pharmacol. 2005;59:302-9.

3. Hansten H and Horn J. The Top 100 Drug Interactions: A Guide to Patient Management. Freeland, Washington: H&H Publications; 2012.