Pharmacy Times – June 2016

 

Drug Interactions: Insights and Observations

 

Contraindication” versus “Avoid Concomitant Use

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References.

1. 1. Corlanor [package insert]. Thousand Oaks, CA: Amgen Inc.; 2015.

2. Mittal SR. Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of ivabradine, diltiazem and ranolazine. J Assoc Physicians India. 2014;62:426-427.

3. Cocco G, Jerie P. Torsades de pointes induced by the concomitant use of ivabradine and azithromycin: an unexpected dangerous interaction. Cardiovasc Toxicol. 2015;15:104-106.

4. Portoles A, Terleira A, Calvo A, Martine I, Resplandy G. Effects of Hypericum perforatum in ivabradine pharmacokinetics in healthy volunteers: an open-label pharmacokinetic interaction clinical trial. J Clin Pharamcol. 2006;46:1188-1194.

5. Vlase L, Neag M, Popa A, Muntean D, Baldea I, Leucuita SE. Pharmacokinetic interaction between ivabradine and carbamazepine in healthy volunteers. J Clin Pharm Therapeutics. 2011;36:225-229.