Pharmacy Times – June 2015


Drug Interactions: Insights and Observations


Drug – Disease – Drug Interaction


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





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3. Aiken AE and Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos. 2007;35:1687–1693.

4. Schmitt C, Kuhn B, Zhang X, et al. Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis. Clin Pharmacol Ther. 2011;89:735-40.

5. Terao K, Tsuru T, Suzaki M et al. Drug-disease interaction study of tocilizumab in patients with rheumatoid arthritis – IL-6 signal inhibition normalized cytochrome P-450 enzymes expression which was reduced by inflammation. Internat J Rheum Dis. 2010;13(Suppl 1):100.