Pharmacy Times – July 2014


Drug Interactions: Insights and Observations


Hyperkalemia from Drug Interactions: New Data


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





1. Eschmann E, Beeler PE, Kaplan V, et al. Patient- and physician-related risk factors for hyperkalemia in potassium-increasing drug interactions. Eur J Clin Pharmacol. 2014;70:215-223.


2. Wrenger E, Mller R, Moesenthin M, et al. Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases. BMJ. 2003;327:147-149.


3. Juurlink DN, Mamdani MM, Lee DS, et al. Rates of hyperkalemia after publication of the randomized aldactone evaluation study. N Engl J Med. 2004;351:543-551.