Pharmacy Times – July 2012


Drug Interactions: Insights and Observations


Yohimbine: Old Drug with New Interactions

John R. Horn, PharmD, FCCP, and Philip D.  Hansten, PharmD





1. Okamoto LE et al. Synergistic effect of norepinephrine transporter blockade and alpha-2 antagonism on blood pressure in autonomic failure. Hypertension. 2012;59:650-656.

2. Lacomblez L et al. Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine. Clin Pharmacol Ther. 1989;45:241-251.