Pharmacy Times – January 2016

 

Drug Interactions: Insights and Observations

 

Drug InteractionsDrugs Affecting Levothyroxine Absorption

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References.

 

1. Trifiro G, Parrino F, Sultana J, et al. Drug interactions with levothyroxine therapy in patients with hypothyroidism: observational study in general practice. Clin Drug Invest. 2015;35:187-195.

2. Irving SA, Vadiveloo T, Leese GP. Drugs that interact with levothyroxine: an observations study from the thyroid epidemiology, audit and research study (TEARS). Clin Endocrinol. 2015;82:136-141.

3. Liwanpo L., Hershman JM. Conditions and drugs interfering with thyroxine absorption. Best Pract Res Clin Endocrinol Metab. 2009;23:781-792.

4. Benvenga S. When thyroid hormone replacement is ineffective? Curr Opin Endocrinol Diabetes Obes. 2013;20:467-477.

5. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA. 2000;283;2822-2825.

6. Sachmechi I, Reich DM, Aninyei M, et al. Effect of proton pump inhibitors on serum thyroid-stimulating hormone level in euthyroid patients treated with levothyroxine for hypothyroidism. Endocr Pract. 2007;13:345-349.

7. Abi-Abib RC, Vaisman M. Is it necessary to increase the dose of levothyroxine in patients with hypothyroidism who use omeprazole? Arq Bras Endocrinol Metabol 2014;58:731-736.

8. Vita R, Saraceno G, Trimarchi F, et al. Switching levothyroxine from the tablet to the oral solution formulation corrects the impaired absorption of levothyroxine induced by proton pump inhibitors. J Clin Endocrinol Metab.