Pharmacy Times – February 2016

Drug Interactions: Insights and Observations

Warfarin and Sulfonylureas: Association But Is It an Interaction?

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References

1. Romley JA et al. Association between use of warfarin with common sulfonylureas and serious hypoglycemic events: retrospective cohort analysis. BMJ. 2015;351:h6223.

2. Glucotrol. [package insert]. New York, NY, Pfizer, Inc., 2013.

3. Amaryl. [package insert]. Bridgewater, NJ, Sanofi-Aventis, LLC, 2013.

4. Hansten PD et al. Drug Interactions Analysis and Management, Wolters Kluwer Health, 2014, pages PM9-13.

5. Skovsted L et al. The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism. Acta Med Scand. 1976;199:513-5.