Pharmacy Times – December 2013

 

Drug Interactions: Insights and Observations

 

Carboxylesterases and Drug Interactions

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

References

 

1. Laizure SC et al. The role of human carboxylesterase in drug metabolism: have we overlooked their importance? Pharmacother. 2013;33:210-22.

2. Tang MJ et al. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol Experiment Ther. 2006;319:1467-76.

3. Shi D et al. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by the antiplatelet agent clopidogrel. J Pharmacol. Exp Ther. 2006;319:1477-84.

4. Xiao D et al. Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs. Biochem Pharmacol. 2013;85:439-47.

5. Lewis JP et al. The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response. Pharmacogen and Genomics. 2013;23:1-8.