Pharmacy Times – December 2011


Drug Interactions: Insights and Observations


Get to Know an Enzyme: CYP2C8


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





1. Rendic S et al. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers and inhibitors. Drug Metab Rev. 1997;29:413-580.

2. Totah RA et al. Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Clin Pharmacol Ther. 2005;77:341-52.

3. Niemi M et al. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide. Diabetologia. 2003;46:347-51.