Pharmacy Times – August 2017

 

Drug Interactions: Insights and Observations

 

Oral Potassium Supplements and Anticholinergic Drugs

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

References:

 

1. Boley SJ, Allen AC, Schultz L et al. Potassium-induced lesions of the small bowel. I. Clinical aspects. JAMA. 1965;193:81-4.

2. Patterson DJ, Weinstein GS, Jeffries GH. Endoscopic comparison of solid and liquid potassium chloride supplements. Lancet. 1983;322 (Nov 5): 1077-8.

3. McMahon FG, Ryan JR, Akdamar K et al. Effect of potassium chloride supplements on upper gastrointestinal mucosa. Clin Pharmacol Ther. 1984;35:852-5.

4. Gonzalez GB, Pak CYC, Adams-Huet B et al. Effect of potassium-magnesium citrate on upper gastrointestinal mucosa. Aliment Pharmacol Ther. 1998;12:105-110.

5. Alsop W, Moore JG, Rollins DE et al. The effects of five potassium chloride preparations of the upper gastrointestinal mucosa in healthy subjects receiving glycopyrrolate. J Clin Pharmacol. 1984;24:235-9.

6. Ryan JR, McMahon GF, Akdamar K et al. Mucosal irritant potential of a potassium-sparing diuretic and of wax-matrix potassium chloride. Clin Pharmacol Ther. 1984;35:90-3.

7. Sinar DR, Bozymski EM, Blackshear JL. Effects of oral potassium supplements on upper gastrointestinal mucosa: multicenter clinical comparison of three formulations and placebo. Clin Therapeutics. 1986;8:157-63.

8. Moore JG, Alsop WR, Freston JW, et al. The effect of oral potassium chloride on upper gastrointestinal mucosa in healthy subjects; healing of lesions despite continuing treatment. Gastrointest Endosc. 1986;32:210-12.