Pharmacy Times – April 2017


Drug Interactions: Insights and Observations


Metformin and Organic Cationic Transporter Interactions


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD






1. Wagner DJ, Hu T, Wang J. Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics. Pharmacol Res. 2016;111:237-46. Doi:10.1016/j.phrs.2016.06.002.

2. Cho SK, Kim CO, Park ES et al. Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers. Br J Clin Pharmacol. 2014;78:1426-32. Doi: 10.1111/pcp.12476.

3. Ahlin G, Chen L, Lazorova L, et al. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions. Pharmacogenomics J. 2011;11:400-11. Doi. 10.1038/tpj.2010.54.

4. Cho SK, Yoon JS, Lee MG et al. Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants. Clin Pharmacol Ther. 2011;89:416-21. Doi.:10.1038/cpt.2010.266.