Pharmacy Times – April 2013


Drug Interactions: Insights and Observations


Diuretics, ACEIs, ARBs and NSAIDs: A Nephrotoxic Combination


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD






1. Horn J et al. Coadministration of NSAIDs and Antihypertensive Agents. Pharmacy Times. 2006;72 (April);54.

2. Thomas MC. Diuretics, ACE inhibitors and NSAIDs – the triple whammy. Med J Aust. 2000;172:184-5.

3. Loboz KK et al. Drug combinations and impaired renal function – the ‘triple whammy’. Br J Clin Pharmacol. 2004;59:239-43.

4. Lapi F et al. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. BMJ. 2013;346:e8525.