Pharmacy Times Š December 2009


Drug Interactions: Insights and Observations


Drug Interactions with St. JohnÕs Wort


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





1.     Horn J and Hansten P. St. JohnÕs Wort Interactions: WhatÕs New? Pharmacy Times. May, 2004, 62.

2.     Piscitelli SC et al. Indinavir concentrations and St. JohnÕs wort. Lancet. 2000;355:547-548.

3.     Wang XD et al. Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: application to a clinical herb-drug interaction study. J Chromatrog B. 2007;852:534-544.

4.     Smith P et al. The influence of St. JohnÕs wort on the pharmacokinetics and protein binding of Imatinib mesylate. Pharmacotherapy. 2004;24:1508-1514.