Drug Interactions: Insights and Observations


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD


Fruit Juice Interactions




  1. Lilja JJ et al. Effects of orange juice on the pharmacokinetics of atenolol. Eur J Clin Pharmacol. 2005;61:337-40.
  2. Saito M et al. Undesirable effects of citrus juice on the pharmacokinetics of drugs. Drug Safety. 2005;28:677-94.
  3. Tirona RG et al. Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv Drug Del Rev. 2002;54:1343-52.
  4. Schwarz UI et al. Grapefruit juice ingestion significantly reduces talinolol bioavailability. Clin Pharmacol Ther. 2005;77:291-301.
  5. Hidaka M et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos. 2005;33:644-8.