Pharmacy Times October 2008

 

Drug Interactions: Insights and Observations

 

Protease Inhibitors and PPIs

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References

  1. Luber A et al. Survey of medication used by HIV-infected patients that affected gastrointestinal (GI) acidity and potential for negative drug interactions with HAART [abstract no. P294], 7th International Congress on Drug Therapy in HIV infection; 2004; Glasgow.
  2. .Agarwala S et al. Pharmacokinetic interaction between atazanavir and omeprazole in healthy subjects [abstract no. WePe3.3C08], 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment; 2005; Rio de Janeiro.
  3. Agarwala S et al. pharmacokinetic effect of omeprazole on atazanavir co-administered with ritonavir in healthy subjects [abstract no. 658] 12th Conference on Retroviruses and Opportunistic Infections; 2005; Boston.
  4. Tomilo DL et al. Inhibition of atazanavir oral absorption by lansoprazole gastric acid suppression in healthy volunteers. Pharmacotherapy. 2006;26:341-6.
  5. Guiard-Schmid JB et al. Proton pump inhibitors do not reduce atazanavir concentrations in HIV-infected patients treated with ritonavir-boosted atazanavir [letter]. AIDS 2005;19:1937-8.
  6. Burger DM et al. pharmacokinetic interaction between the proton pump inhibitor omeprazole and the HIV protease inhibitor indinavir. AIDS. 1998;12:2080-2.
  7. Tappouni HL et al. Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir. Am J Health Syst Pharm. 2008;65:422-8.
  8. Fang AF et al. Significant decrease in nelfinavir systemic exposure after omeprazole coadministration in healthy subjects. Pharmacotherapy. 2008;28:42-50.
  9. Winston A et al. Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers. AIDS. 2006;20:1401-6.
  10. Singh K et al. Pharmacokinetics and safety of saquinavir/ritonavir and omeprazole in HIV-infected subjects. Clin Pharmacol Ther. 2008;83:867-72.