Goldenseal Drug Interactions



September 2012


John R. Horn, PharmD, FCCP, and Philip D.  Hansten, PharmD





1. Gurley BJ et al. Effect of goldenseal (Hydrastis Canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2007;35:240-245.

2. Guo Y et al. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68:213-217.

3. Gurley BJ et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes. Clin Pharmacol Ther. 2005;77:415-426.

4. Gurley BJ et al. Supplementation with goldenseal (Hydrastis Canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A4 activity in vivo. Clin Pharmacol Ther. 2008;83:61-69.

5. Wu X et al. Effects of berberine on the blood concentration of cyclosporine A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol. 2005;61:567-572.

6. Gurley BJ et al. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. JohnÕs wort, and Echinacea. Mol Nutr Rood Res. 2008;52:755-763.