Pharmacy Times – Sept 2006


Drug Interactions: Insights and Observations


Genetics and Drug Interactions: Understanding an Important Variable in Patient Response


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD



  1. Hamelin, B. A et al. Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity. Clin Pharmacol Ther. 2000;67:466-477.
  2. Caraco Y et al. Impact of ethnic origin and quinidine coadministration on codeine’s disposition and pharmacodynamic effects. J Pharmacol Exp Ther. 1999;290:413-422.
  3. Qiao H-L et al. Pharmacokinetics of three proton pump inhibitors in Chinese subjects in relation to the CYP2C19 genotype. Eur J Clin Pharmacol. 2006;62:107-112.
  4. Itagaki F et al. Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations. J Pharm Pharmacol. 2004;56:1055-1059.