Pharmacy Times – Sept 2006
Drug Interactions: Insights and Observations
Genetics and Drug
Interactions: Understanding an Important Variable in Patient Response
John R. Horn, PharmD,
FCCP and Philip D. Hansten, PharmD
B. A et al. Significant interaction between the nonprescription
antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in
healthy men with high or low CYP2D6 activity. Clin Pharmacol Ther.
- Caraco Y
et al. Impact of ethnic origin and quinidine coadministration on codeine’s
disposition and pharmacodynamic effects. J Pharmacol Exp Ther.
- Qiao H-L et al. Pharmacokinetics of three proton pump
inhibitors in Chinese subjects in relation to the CYP2C19 genotype. Eur J
Clin Pharmacol. 2006;62:107-112.
- Itagaki F
et al. Effect of lansoprazole and rabeprazole on tacrolimus
pharmacokinetics in healthy volunteers with CYP2C19 mutations. J Pharm