Pharmacy Times – Sept 2006

 

Drug Interactions: Insights and Observations

 

Genetics and Drug Interactions: Understanding an Important Variable in Patient Response

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

References

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  2. Caraco Y et al. Impact of ethnic origin and quinidine coadministration on codeine’s disposition and pharmacodynamic effects. J Pharmacol Exp Ther. 1999;290:413-422.
  3. Qiao H-L et al. Pharmacokinetics of three proton pump inhibitors in Chinese subjects in relation to the CYP2C19 genotype. Eur J Clin Pharmacol. 2006;62:107-112.
  4. Itagaki F et al. Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations. J Pharm Pharmacol. 2004;56:1055-1059.