Pharmacy Times – June 2011


Drug Interactions: Insights and Observations


Calcium-Channel Blockers and CYP3A4 Inhibitors: Watch Out for Enhanced Cardiovascular Response


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD





1. Wright AJ et al. The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers. CMAJ. 2011;183:303-307.

2. Liedholm H et al. Erythromycin-felodipine interaction. DICP. 1991;25:1007-1008.

3. Kaeser YA et al. Severe hypotension and bradycardia associated with verapamil and clarithromycin. Am J Health-Syst Pharm. 1998;55:2417-2418.

4. Reed M et al. Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005;39:357-360.

5. Geronimo-Pardo M et al. Clarithromycin-nifedipine interaction as possible cause of vasodilatory shock. Ann Pharmacother. 2005;39:538-542.