Pharmacy Times – June 2008

 

Drug Interactions: Insights and Observations

 

Warfarin Drug Interactions: The Role of Genetics

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

References

1. Holbrook AM, et al. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med. 2005;165:1095-1106.
2. Penning-van Beest F, et al. Main comedications associated with major bleeding during anticoagulant therapy with coumarins. Eur J Clin Pharmacol. 2005;61(5-6):439-44.
3. Kamali F, et al. The future prospects of pharmacogenetics in oral anticoagulation therapy. Br J Clin Pharmacol. 2006;61:746-51.
4. Rieder MJ et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med. 2005;352:2285-93.