Pharmacy Times June 2006


Drug Interactions: Insights and Observations


Be on the Alert for Increasing Drug Interactions with Statins


John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD




  1. Zocor package insert. Whitehouse Station, NJ: Merck & Co; 2005.
  2. Shanahan RL, et al. Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization. Pharmacotherapy. 2005;25:345-351.
  3. Neuvonen PJ, et al. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther. 1996;60:54-61.
  4. Kantola T, et al. Erythromycin and verapamil considerably increase simvastatin and simvastatin acid concentrations. Clin Pharmacol Ther. 1998;64:177-182.
  5. Graham DJ, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA. 2004;292:2585-2590.
  6. Rogers JD, et al. Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Clin Pharmacol Ther. 1999;66:358-366.
  7. Hansen K, et al. Outcomes in 45 patients with statin-associated myopathy. Arch Intern Med. 2005;165:2671-2676.
  8. Hansten PD, Horn JR. The Top 100 Drug Interactions: A Guide to Patient Management. 2006 ed. Freeland, WA: H&H Publications LLP: 161-173.