Pharmacy Times MAY 2010

 

Drug Interactions: Insights and Observations

 

 

Does Menthol Affect Warfarin Response?

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

 

1. Coderre K, et al. Probable warfarin interaction with menthol cough drops. Pharmacotherapy 2010;30:50e-52e.

2. Kassebaum PJ, et al. Possible warfarin interaction with menthol cough drops. Ann Pharmacother 2005;39:365-367.

3. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;18:2273-2281.

4. Okuyemi KS et al. Does menthol attenuate the effect of bupropion among African American smokers? Addition 2003;98:1387-1393.

5. Benowitz NL et al. Mentholated cigarette smoking inhibits nicotine metabolism. J Pharmacol Exp Ther 2004;310:1208-1215.

6. Gelal A, et al. Effect of menthol on the pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. Eur J Clin Pharmacol 2005;60:785-790.

7. Dresser GK, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-255.

8. Gelal A et al. Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers. Eur J Clin Pharmacol 2003;59:417-422.