Pharmacy Times – February 2010
Drug Interactions: Insights and Observations
Clopidogrel – Proton Pump Inhibitor Interaction: An Update
John R. Horn, PharmD,
FCCP and Philip D. Hansten, PharmD
- Kazui M, et al. Identification
of the human cytochrome P45o enzymes involved in the two oxidative steps
in the bioactivation of clopidogrel to its pharmacologically active
metabolite. Drug Metab Disp. 2010;38:92-99.
- Gilard M, et al. Influence of
omeprazole on the antiplatelet action of clopidogrel associated with
aspirin. J Am Coll Cardiol. 2008;51:256-60.
- Ho PM, et
al. Risk of adverse outcomes associated with concomitant use of
clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA.
DN, et al. A population-based study of the drug interaction between proton
pump inhibitors and clopidogrel. CMAJ.2009;180(7):713-8.
- Pezella E,
et al. Initial assessment of clopidogrel impact of a drug interaction
between clopidogrel and proton pump inhibitors. JACC. 2008;52:1038–1039.
- Stanek EJ,
et al. Abstract O-11: A national study of the effect of individual proton
pump inhibitors on cardiovascular outcomes in patients treated with
clopidogrel following coronary stenting: The Clopidogrel Medco Outcomes
Study. Presented at: The Society for
Cardiovascular Angiography and Interventions, 2009; Las Vegas, NV.
ML, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and
prasugrel with or without a proton-pump inhibitor: an analysis of two
randomized trials. Lancet. 2009;347:989-97.
- Rassen JA,
et al. Cardiovascular outcomes and mortality in patients using clopidogrel
with proton pump inhibitors after percutaneous coronary intervention or
acute coronary syndrome. Circulation.2009;120:2322-39.
- Bhatt DL,
et al. The COGENT Trial. Presented at Transcatheter Cardiovascular
Therapeutics, 2009; San Francisco, CA. Available at: http://assets.cardiosource.com/Bhatt_COGENT.ppt.
- Information for Healthcare Professionals: Update to
the labeling of Clopidogrel Bisulfate (marketed as Plavix) to alert
healthcare professionals about a drug interaction with omeprazole
(marketed as Prilosec and Prilosec OTC). Food and Drug Administration.
Available online at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm190787.htm.