Pharmacy Times – February 2007

 

Drug Interactions: Insights and Observations

 

Rx Irony: Drug Interactions for Pharmacoenhancement

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

 

References

  1. Somogyi A, McLean A, Heinzow B.Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs. Eur J Clin Pharmacol. 1983;25(3):339-45.
  2. Bauer LA, Black D, Gensler A. Procainamide-cimetidine drug interaction in elderly male patients. J Am Geriatr Soc. 1990 Apr;38(4):467-9.
  3. Bourge RC, Kirklin JK, Naftel DC, et al. Diltiazem-cyclosporine interaction in cardiac transplant recipients: impact on cyclosporine dose and medication costs. Am J Med. 1991 Mar;90(3):402-4.
  4. Smith CL, Hampton EM, Pederson JA, et al. Clinical and medicoeconomic impact of the cyclosporine-diltiazem interaction in renal transplant recipients. Pharmacotherapy. 1994 Jul-Aug;14(4):471-81.
  5. Kempf DJ, Marsh KC, Kumar G, et al. Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by codaministration with ritonavir. Antimicrob Agents Chemother. 1977;41:654-60.
  6. Motwani B and Khayr W. Pharmacoenhancement of protease inhibitors. Am J Ther. 2006;13:57-63.