Drug Interactions: Insights and Observations


Interactive Properties of Tizanidine (Zanaflex)


John R. Horn, PharmD, FCCP, and Philip Hansten, PharmD




1. Granfors MT et al. Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction. Clin Pharmacol Ther. 2004;75:331-41.

2. Johnson TR, Tobias JD. Hypotension following the initiation of tizanidine in a patient treated with an angiotensin-converting enzyme inhibitor for chronic hypertension. J Child Neurol. 2000;15:818-819.

3. Kao CD et al. Hypotension due to interaction between lisinopril and tizanidine. Ann Pharmacother. 2004;38:1840-43.