Drug Interactions: Insights
and Observations
Interactive Properties of Tizanidine
(Zanaflex)
John
R. Horn, PharmD, FCCP, and Philip Hansten, PharmD
References:
1. Granfors MT et
al. Fluvoxamine drastically increases concentrations and effects of tizanidine:
a potentially hazardous interaction. Clin Pharmacol Ther. 2004;75:331-41.
2. Johnson TR,
Tobias JD. Hypotension following the initiation of tizanidine in a patient
treated with an angiotensin-converting enzyme inhibitor for chronic hypertension.
J Child Neurol. 2000;15:818-819.
3. Kao CD et al.
Hypotension due to interaction between lisinopril and tizanidine. Ann
Pharmacother. 2004;38:1840-43.